Systems Medicine in Colorectal Cancer: From a Mathematical Model Toward a New Type of Clinical Trial

September 5, 2016August 2, 2017 Publications, Reviews

In this review, we primarily focus on and aim towards combination therapies with targeted drugs: inhibitors of signaling proteins affected by excess of function.

Clinical implications of omics and systems medicine: focus on predictive and individualized treatment

August 28, 2015August 28, 2015 Publications, Reviews

The aims of this review are to provide a brief introduction to systems medicine and discuss how it may contribute to the clinical implementation of individualized treatment, using clinically relevant examples.

Modules, networks and systems medicine for understanding disease and aiding diagnosis

May 29, 2015July 28, 2015 Publications, Reviews

This review explains and provides examples of how network-based analyses of omics data, in combination with functional and clinical studies, are aiding our understanding of disease, as well as helping to prioritize diagnostic markers or therapeutic candidate genes.